Common variants of cGKII/PRKG2 are not associated with gout susceptibility.
نویسندگان
چکیده
OBJECTIVE Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. METHODS Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. RESULTS cGKII variants have no association with gout. CONCLUSION Our replication study suggests that cGKII is not involved in gout susceptibility.
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ورودعنوان ژورنال:
- The Journal of rheumatology
دوره 41 7 شماره
صفحات -
تاریخ انتشار 2014